| Detroit at Chicago | 1:00 PM | FOX | Soldier Field | |
| Cincinnati at Cleveland | 1:00 PM | CBS | Cleveland Browns Stadium | |
| Seattle at Indianapolis | 1:00 PM | FOX | Lucas Oil Stadium | |
| NY Giants at Kansas City | 1:00 PM | FOX | Arrowhead Stadium | |
| Baltimore at New England | 1:00 PM | CBS | Gillette Stadium | |
| Tampa Bay at Washington | 1:00 PM | FOX | FedEx Field | |
| Tennessee at Jacksonville | 1:00 PM | CBS | Jacksonville Stadium | |
| Oakland at Houston | 1:00 PM | CBS | Reliant Stadium | |
| NY Jets at New Orleans | 4:05 PM | CBS | Superdome | |
| Buffalo at Miami | 4:05 PM | CBS | Land Shark Stadium | |
| St. Louis at San Francisco | 4:15 PM | FOX | Candlestick Park | |
| Dallas at Denver | 4:15 PM | FOX | Invesco Field at Mile High | |
| San Diego at Pittsburgh | 8:20 PM | NBC | Heinz Field | |
| MON, OCT 5 | TIME (ET) | TV | LOCATION | |
| Green Bay at Minnesota | 8:30 PM |  |
Metrodome |
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