Hall of Fame pitcher Nolan Ryan was on the same pitching staff with Danny Darwin during the 1986 through 1988 seasons. Both were described by Milo Hamilton as "tall, tough Texans." It was a source of debate amongst Astros players and fans over who would win in a fight, Ryan or Darwin. Though Astros pitcher Bob Knepper attempted to set up a fight between the two during spring training in 1988, manager Hal Lanier stopped it before it could commence. Many experts, including Astros shortstop Rafael Ramirez, felt that Darwin would win because he "looked like someone no man would want to mess with."

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