Since its formation, recording and touring lineups of the band have included co-founders Deily and Peretz,John Strohm (Blake Babies), Doug Trachten, Corey Loog Brennan, Byron Hoagland (Folks On Fire), Ben Daughtrey (Squirrel Bait), Juliana Hatfield (Blake Babies), Nic Dalton (Godstar, Sneeze, The Plunderers), Dave Ryan, Patrick "Murph" Murphy (Dinosaur Jr), Josh Lattanzi, Bill Gibson (Eastern Dark), Mark 'Budola' Newman, Kenny Lyon, Vess Ruhtenberg, Devon Ashley, Karl Alvarez and Bill Stevenson (Descendents), P. David Hazel and various others.
After their initial punk-influenced releases and tours as an independent/"college rock" band in the late '80s, the Lemonheads' popularity with a mass audience grew in 1992 with the major label album It's a Shame about Ray, which was produced, engineered, and mixed by The Robb Brothers (Bruce Robb, Dee, and Joe). This was followed by a cover of Simon and Garfunkel's "Mrs. Robinson", which eventually became one of the band's most successful singles. The Lemonheads were active until 1997 before going on hiatus, but reformed with a new lineup in 2005 and released The Lemonheads the following year. The band released its latest album, Varshons, in June 2009.